My recommended malware tool of the week is Dr.Web CureIt! This is a free download from their homepage, and is freeware for home users. I have been amazed at the effectiveness of this product, it is able almost every time to detect viruses that traditional scanners can not. Most effectively trojans and rootkits. Dr.Web CureIt! has also been effective at detecting TDSS and its variants, however it seems removal of the TDSS backdoor still remains a little more complex (See the removal instructions for TDSS)

Dr.Web CureIt! detects and neutralizes viruses, rootkits, Trojan horses, spyware, and other malicious objects that have gone undetected by your anti-virus software.

Used in conjuction with your background scanner and other tools, Dr.Web CureIt! is a powerful tool in your anti-malware arsenal.